Q: How would I setup the filters to accomplish this? Could you give me an insight on how to set that filter up?A: do this:Go to Admin panel -> Manage -> Ticket FiltersClick Add New Filter (upper right)name it department email-filter-abc.comExecution order 1, tick "Stop Processing on further match!"Select Filter Status: Enableunder Target Channel select Emails.under Filter Actions, there are two drop downs and text field.in the first choose Ticket / Issue Summary, Contains, abc.comSelect the department in the Department dropdown, click save.repeat this process creating a new filter for def.com.Q: can different departments have different signaturesA: Yes departments can have their own signatures.Do this: Admin panel -> Agents -> Departments.Click on abc.com department.Fill out the Department Signature box at the bottom.Click Save Changes.