Did you try any of the step that I suggested to you in the last couple posts I made to you?Here they are again:The connection timed out means that you cannot reach the mail server.
You should check your firewalls, and with your hosting provider to make
sure that you are using the correct settings.After thought:Do you have command line access to the webserver?You could try to telnet smtp.1und1.de 465. If you get a timeout as well its not osTicket or PHP. You could also try downgrading to PHP 5.5 and seeing of that helps.